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Aloe Vera to Prevent Immune Failure

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Cal Crilly 22nd March 2018

It is of interest that one of the main cures for immune failure and T-cell suppression (Aloe Vera) was found in the same laboratories that Robert Gallo used the year before Gallo blamed AIDS and immune failure seen in gays on our retroviruses.

“It has been shown that sugar molecules can provide exquisite specificity to cell surface structures such as blood group determinants; may be necessary for cell-cell contact required for fertilization, differentiation, cell aggregation, and infection with viruses and bacteria; may be involved in the interaction between natural killer cells, cytotoxic T cells, and suppressor T cells with their targets; and provide receptors required for cell activation by mitogens.”

“We have used T cells obtained from the peripheral blood of patients with acute Epstein-Barr virus (EBV)'-induced infectious mononucleosis (IM) as a source of suppressor T lymphocytes, since during this illness suppressor T cells become activated that profoundly inhibit immunoglobulin (Ig) production in vitro. Our results demonstrate that D-mannose and some of its derivatives can significantly reverse suppression by the T cells and suggest an important role for certain sugars as recognition and regulatory signals for the immune system.”

“A Rolefor Sugars in Suppressor Celll Target Interactions . Acute EBV-induced IM is associated with the appearance in the peripheral blood of activated suppressor T lymphocytes that profoundly inhibit B cell activation in vitro.”

REVERSAL OF INFECTIOUS MONONUCLEOSIS-ASSOCIATED SUPPRESSOR T CELL ACTIVITY BY D-MANNOSE

Journal of Experimental Medicine - Volume 158, October 1983

 “One day I got a strange call. Dr. Terry Pulse, a physician in Texas, was having what appeared to be unbelievable success treating HIV positive patients with whole leaf aloe vera. I called Dr. Pulse. He told me that he had been conducting a study of 30 HIV positive patients (one non-compliant patient dropped out of the study, reducing the number of 29).

Simplified considerably, the group of 29 broke down as follows: based on the modified Walter Reed Score (a method of determining from a set of factors the stage of AIDS development), fifteen had full blown AIDS. Twelve of the subjects met the criteria for AIDS Related Complex (ARC), and the remaining two were HIV seropositive but were asymptomatic. In other words, they were at three different stages of the infection.

The patients were put on a daily regimen of nutritional supplements and a minimum of 1200 milligrams of the active ingredients found in whole leaf aloe vera juice.

After six months, 27 of the 28 patients had improved on their Walter Reed scores. All had improved on the Karnofsky Quality of Life Assessment Scores. There were substantial improvements in other medical tests indicating such things as an

increase in the T-4 cell count (which reflects a boosting of the immune system) and a drop in the P-24 core antigen activity.

I remember asking Dr. Pulse what he had concluded from his study. He stated, "Aloe is to an AIDS patient such as insulin is to a diabetic." He further told me that his study clearly showed that aloe vera played an active role in halting the progression of the AIDS virus.

I learned from Dr. Pulse that another study had been conducted by Dr. H. Reginald McDaniel, Chief of Pathology at Dallas-Fort Worth Medical Center. He had treated sixteen AIDS patients using 1,000 mg a day of orally administered aloe. His study reflected that, after six months, six patients with advanced cases of AIDS showed a 20% improvement in symptoms while less seriously ill patients improved by an average of 71%. Dr. Pulse further confirmed that, like his tests, Dr. McDaniel's also reflected a drop in HIV antibody positive cell culture. Also, symptoms such as fever, night sweats, diarrhea, and opportunistic infections were either eliminated or significantly reduced in all patients.

After Dr. Pulse shared his research information and the results of treating AIDS patients with aloe vera, I travelled to his clinic, interviewed the doctors, the staff, and AIDS patients and videotaped what was occurring. First Dr. Pulse reviewed his study as we recorded it on video. Then the patients arrived and one by one we taped their stories. These were patients who had previously been very sick with AIDS. They had been confined to their beds, unable to work. They had the characteristic symptoms, including night sweats, nausea, and vomiting. They had been told by doctors that they were nearing the end and that nothing really could be done for them. The stories they told were astounding. With T-4 helper cell counts starting below 200 (frequently substantially below) the counts had climbed to numbers like 400, 500, 800, and their symptoms had disappeared.”

Aloe Vera and AIDS

Excerpts from "Aloe Vera: A Mission Discovered"
by Lee Ritter

The reason Aloe Vera works is because it is an IDO inhibitor which is an enzyme that can flick our white blood cells to a type that causes fibrosis and prevents a proper immune response to remove infections.

To summarise a complex subject, our white blood cells (macrophages) have 2 types.

M1 macrophages get in and dig out rubbish whether it is old collagen or infections from bacteria and fungus.

The other types are M2 macrophages, they seem to have 2 functions, one is to dig out large scale infections such as TB and malaria or anything big stuck in the body.

To do this they bind together like a rugby scrum and these are called giant cell multinucleated macrophages, they also work with other immune cells to deposit collagen for repairing damaged areas of the body.

If there is a large infected area say with TB or malaria the white blood cells encircle the area first with collagen and then pour peroxide and nitric oxide in to dissolve everything and kill it.

To become M2 macrophages or bind together into the rugby scrum type the white blood cells use our own retroviruses to fuse together into the giant multinucleated cells.

In the last decade retroviruses have been found to fuse sperm and eggs, they are needed in pregnancy, are used fuse osteoclasts to remove bone and fuse muscles together.

This is what so called HIV scientists have been measuring for years, they have seen retroviruses in white blood cells and being paranoid virologists confused our functional retroviruses for some sort of infection of white blood cells.

HIV/AIDS in my opinion has been a muddled mess since the word go.

The other aspect of Aloe Vera apart from being an IDO inhibitor is the mannose sugars allow the white blood cells to attach to old collagen and take it out so a deficiency in mannose sugars causes fibrosis (too much collagen) and poor blood flow.

When cancer occurs the tumours release IDO which in effect tells the immune system to leave the cancer cells alone.

Much worse than that is the white blood cells then become M2 macrophages and using our own retroviruses again they will get confused and fuse to the tumour cells and then release collagen destroying enzymes (MMPs) which allow the tumour to spread.

Immune stimulants like zinc are involved in breaking down our collagen, if someone has cancer and IDO is active and M2 macrophages are active then the zinc is like adding petrol to the site and will help the tumour to spread.

“Tumor cells escape the immune surveillance system of the host through a process called immune tolerance. Immunotherapy targets molecules that serve as checks and balances in the regulation of immune response. Indoleamine-2,3-dioxygenase (IDO) is an intracellular enzyme, which through the process of tryptophan depletion exerts an immunosuppressive effect, facilitating immune escape of tumors. This review summarizes our current knowledge on IDO expression in malignancies, the IDO inhibitors that are currently available and those under clinical development.”

Targeting the indoleamine 2,3-dioxygenase pathway in cancer

Adding in mannose sugars first flicks the immune system back to the M1 macrophage mode and the white blood cells can then see the cancer cells, recognise them and remove them.

Aloe Vera is an IDO inhibitor, green tea, broccoli, cauliflower, cabbage and papaya leaf tea also seems to be IDO inhibitors which flick the immune system in the right direction, all of them have anti-cancer properties regardless of IDO inhibition.

If eating Aloe is not suitable for taste or the stomach then the gel from leaves can also be rubbed into the skin for absorption, I rub Aloe from the leaves into my neck for neck spinal osteo, it soaks in within minutes.

“In this phytochemical study, 18 known compounds were isolated from aqueous dissolved Aloe exudates. All of the isolated compounds were examined for their ability to inhibit IDO activities for a series of anthraquinone derivatives isolated from the Aloe extract; the IC50values of these compounds ranged from 39.41 to 53.93 µM. Enzyme kinetic studies of their modes of inhibition indicated that all of the compounds were uncompetitive inhibitors.”

“The aqueous dissolved Aloe exudate can be used as a source of novel natural IDO inhibitors and merit testing as therapeutic agents in the treatments of cancer and immunopathologic diseases, such as autoimmune, inflammatory, and allergic disorders.”

Chemical Components from Aloe and their Inhibition of Indoleamine 2, 3-dioxygenase

Foods that prevent the cell fusion with tumours are bromelain from pineapples, green tea, turmericolives and olive oil, black cumin, Other foods that suppress tumours are sulphur and selenium foods like garlic and brazil nutsresveratrol from grapes and berries, all purple foods like beetrootpomegranates and berries, herbs like sage, thymerosemary and oregano, plus tomatoes, can you see the Mediterranean diet here?

Bromelain and turmeric are strong blood thinners so not to be used with Warfarin.

This is the effect of IDO on T-cells which are road markers for the macrophages to either come in and rip up the tarmac (damaged or infected areas) or come in and lay down concrete (collagen).

“In conclusion, IDO through GCN2 kinase activation inhibits CD4(+) T-cell proliferation and down-regulates key enzymes that directly or indirectly promote Fatty Acid synthesis, a prerequisite for CD4(+) T-cell proliferation and differentiation into effector cell lineages.”

Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells.

It should be noted that white blood cells are as busy taking out old collagen and making new collagen in all diseases like heart disease, arthritis, osteoarthritis, Crohn’s disease, nerve diseases and so on.

The immune system is not there merely for infections and this myth needs to be flipped on its head, if you say are poisoning your body with sugar and alcohol then cells are dying so the immune system then must keep up with the debris that is clogging up arteries and organs.

The Catch 22 with inflammatory diseases like heart disease, arthritis and osteoarthritis, is the immune system is in the M1 macrophage mode with CD4 T-cells causing much of the inflammation and collagen breakdown as the immune system tries to dig out rubbish.

While the M2 macrophages are causing bad fibrosis or clogging arteries.

Aloe Vera can tag damaged collagen for removal but it stimulates the immune system so care needs to be taken with Aloe Vera use.

To treat heart disease, arthritis and osteoarthritis you need a lot of vitamin C for collagen repair (lemons are excellent for example as they reduce acidity and uric acid via potassium citrate) and anti-inflammatories like the anti-cancer foods I mentioned.

Uric acid keeps M2 macrophages busy trying to remove the uric acid crystals so uric acid and gout drives us towards cancer.

Lemons with orange juice or pineapple should be eaten before meals as they help digest food.

 “Inflammation is the physiological response of the body to harmful stimuli, such as injury, pathogens, damaged cells, or irritants. Inflammatory response can be either acute or chronic, which leads to pathology. The major function of innate immune cells is identification and recognition of the injurious and/or foreign substances causing the defense response. Macrophages are actively involved in all phases of inflammation, and their role as effector and regulatory cells is now widely recognized. Another interesting and important role of macrophages is their high level of specialization and tissue specificity. While all tissue-bound macrophages differentiate from circulating monocytes, they acquire distinct characteristics and functions locally due to their response profiles. One of the major factors for this diversity is the complexity of microbial load as well as tissue architecture.”

Remarkable Role of Indoleamine 2,3-Dioxygenase and Tryptophan Metabolites in Infectious Diseases: Potential Role in Macrophage-Mediated Inflammatory Diseases

These studies below are all diseases where IDO activity rises as people get ill.

High activity of indoleamine 2,3 dioxygenase enzyme predicts disease severity and case fatality in bacteremic patients.

Serum activity of indoleamine 2,3-dioxygenase predicts prognosis of community-acquired pneumonia.

 “The patients who died had significantly higher concentrations of Kyn and significantly lower Tryptophan concentrations, resulting in significantly higher IDO activity”

Serum indoleamine 2,3-dioxygenase activity predicts prognosis of pulmonary tuberculosis.

“High IDO activity in winter predicted subsequent activation of SLE in spring and summer. Our results indicate that IDO-dependent immunosuppressive mechanisms are activated in SLE patients.”

Indoleamine 2,3-dioxygenase activity is increased in patients with systemic lupus erythematosus and predicts disease activation in the sunny season.

Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis

Plasma Indoleamine 2, 3-Dioxygenase, a Biomarker for Tuberculosis in Human Immunodeficiency Virus-Infected Patients

Epstein-Barr Virus Infection Induces Indoleamine 2,3-Dioxygenase Expression in Human Monocyte-Derived Macrophages through p38/Mitogen-Activated Protein Kinase and NF-?B Pathways: Impairment in T Cell Functions

Type 2 diabetes can be described as a disease where long term CD4 T-cell activity and white blood cells have caused massive inflammation leading to damage of pancreatic cells.

Towards the end stage of diabetes the immune system has flopped and people get gangrene and infections, this is where Aloe Vera use can flick the immune system back on so people survive, of course vitamin C plus anti-inflammatory foods in the Mediterranean diet should have been used well before this end stage to lower inflammation and allow collagen repair.

“IDO activity increased with severity of chronic kidney disease”

Increased indoleamine 2,3-dioxygenase activity in type 2 diabetic nephropathy

HAART or Antiretrovirals for so called HIV/AIDS are mild IDO inhibitors which is why they partly work but the side effects make them an expensive and hit or miss therapy because they cause liver damage and lipodystrophy.

Antiretroviral drugs also cause inflammation which is why they stimulate T-cells.

“Among 76 participants, higher baseline IDO activity was associated with lower CD4+ T cell counts (P<0.05) and higher plasma sCD14 levels (P<0.001). After 1 year of HAART, IDO activity decreased significantly (P<0.01), but was still higher than in healthy controls (P<0.05). The baseline IDO activity did not predict CD4+ T cell recovery after 1 year of therapy. The percentages of myeloid and plasmacytoid dendritic cells were not correlated with IDO activity.

Conclusions

IDO activity is elevated in HIV-infected patients, which is partially associated with microbial translocation. HAART reduced, but did not normalize the activity of IDO.”

Anti-Retroviral Therapy Decreases but Does Not Normalize Indoleamine 2,3-Dioxygenase Activity in HIV-Infected Patients

Vitamin B6 is an IDO inhibitor because it raises serotonin, our main anti-depressant which is created from tryptophan, when IDO levels rise tryptophan levels go lower because IDO is breaking it down and people can get depressed.

If people get depressed they chew through tryptophan and this also proves therapies like massage, meditation, watching comedies, doing art, playing music or moderate exercise like walking in the sun are literally antidepressants which can lower IDO and turn on your immune system.

Excessive exercise is counter-productive because it lowers tryptophan and can raise IDO, take note fitness junkies.

Cheese has a good amount of tryptophan, I use it as a source to go back to sleep at night. Anyone on a low protein diet is likely to have low tryptophan.

This is a basic list of tryptophan foods from Wiki “chocolate, oats, dried dates, milk, yogurt, cottage cheese, red meat, eggs, fish, poultry, sesame, chickpeas, almonds, sunflower seeds, pumpkin seeds, buckwheat, spirulina, and peanuts.”

Protein therefore can be part of anti-depressant therapy.

“The enzyme indoleamine 2,3-dioxygenase is induced by proinflammatory cytokines and may form a link between immune functioning and altered neurotransmission, which results in depression. Increased indoleamine 2,3-dioxygenase activity may cause both tryptophan depletion and increased neurotoxic metabolites of the kynurenine pathway, two alterations which have been hypothesized to cause depression.”

A biological pathway linking inflammation and depression: activation of indoleamine 2,3-dioxygenase

As a final point on the link between depression and immune failure and triggering off the IDO enzyme which then depletes Tryptophan, giving out death sentences should be mentioned.

Voodoo and bone pointing curses are a reality in our modern world because hi-tech testing machines that detect a ‘possible’ life threatening illness can have the same effect as bone pointing curses.

HIV antibody tests without ever being proven to detect an immunodeficiency virus have now been doled out willy-nilly now for 34 years, some people have just gone away and committed suicide the curse is so potent.

This is exactly the case with cancer diagnosis and doctors should be aware of the power they have and there is a fine line between breaking it gently and telling someone to go away and die, because the diagnosis as seen from the IDO data will wipe out someone’s immune system in a jiffy all via their mind.

I also believe in psychic attack and online bullying is now a form of psychic attack as seen from child suicides after social media bullying and texting.

Anyone familiar with the HIV controversy will have seen people who chose not to medicate with AIDS drugs get the most incredible abuse online, people literally saying if you don’t take your drugs “you will die” and they were “told to die”.

This is Voodoo and psychic attack and should not to be tolerated.

If someone chooses not to risk the side effects of medication have some respect.

Those people who try to treat their own way are pioneers in experimenting, they may find cures to all sorts of disease so listen to them and learn.

Around 13 years ago I did interviews via my local radio station 4ZZZ here in Australia to people who had drastically different views on what a HIV curse meant.

One of them was Michael Ellner who used hypnotherapy very successfully in New York to treat so called AIDS patients, this is because he was training their minds to flick off enzymes like IDO and flick the immune system back on.

This interview made me believe in hi-tech voodoo.

Michael Ellner died just recently, I think it’s fitting to channel a caring soul and let people have a listen to what he said because it’s relevant to this subject.

Michael Ellner Interview 2005.

The last point is fear causes a rise in cortisol and adrenal failure, in the modern world our computers are now raising cortisol stress hormones with lack of sleep and causing immune failure.

I wrote about that here.

Light at Night Exposure, Diabetes, PCOS and Chronic Fatigue

Aloe Vera and Cancer - Dr. R. McDaniel

https://www.youtube.com/watch?v=rlCECobEKdE

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