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How HAART was Invented?

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Cal Crilly

This piece of history explains how HAART was devised, it was an awkward moment in 1993 when Glaxo had to admit that AZT had killed everybody from 1987 to 1993 and so Fauci and fellow criminals decided to lower the dose and repackage AZT with other drugs and called it HAART, same difference, slower death. Famous people that died on AZT during that time were Freddie Mercury, Kenny Everett and Rudolph Nureyev plus hundreds of thousands of gay men conned into taking AZT as a 'cure' for AIDS.

Controversy of Early AZT Usage Divides the Berlin AIDS Conference

Angry,” “Frustrating,” Controversial," and "Confusing."

These are the words Doug Nelson used to describe and characterize the International Conference on AIDS being held in Berlin in Germany.

Nelson, the Executive Director of the Milwaukee AIDS Project. (MAP}, reporting by phone, said that the major debate, the "scientific controversy and confusion" was over the results of the Concorde Study and the American response to it. The results of the Study were reported to the Berlin Conference on the morning of June 8, 1993.

The recently Completed Concorde Study, done in Great Britain, was a 4-year study of 1,700 people on the effects of AZT on Inhibiting the replication of HIV, the virus 'thought' to cause AIDS.

The Study indicates that early AZT therapy for people who are HIV positive but asymptomatic makes 'no significant difference in either the progression of the disease or in individual survival when the drug is used alone.

The Concorde Study is the longest study on AZT as a single drug therapy.

Because of its length, Nelson said. Its results have had a "powerful" effect on the Conference.

"The Concorde Study is casting shadow over the use of AZT alone," Nelson said,

American scientists are pointing out that Concorde studied AZT alone.

The British researchers did not study the effect of AZT when given in combination with drugs such as DDI or ddC.

The Americans, Nelson said, are raising the issue Of combination drug therapies as the direction we are heading.

"That is the debate in this whole conference," Nelson said.. "There is no consensus on any conclusion. The scientific community is now divided."

Nelson added that to him and others attending the Conference, this is "frustrating in the extreme, The controversy demonstrates to me" Nelson said, "that after 13 years of this epidemic, there are no answers. We have only scratched the surface."

Fauci speaks to the Conference.

On Tuesday, June 8. 1993, Dr. Anthony Fauci, Director of the National Institutes of Health,. Office of AIDS Research in Washington, D.C. According to Nelson. Fauci said that the research he has been involved with shows that in the first 12 weeks after infection with HIV, replication of the virus is very high in the lymphatic system.'

Fauci 'also reported thathis studies show that immune 'system activation is profound in the first 12 weeks. Activation is a profound way makes the T cells more susceptible to infection.

Nelson said that "It's a catch-22. We have in find ways to enhance the immune system without triggering profound activation of that system and thus leaving person more open to infection..

Nelson said that Fauci gave no answers, no way to do this. "'This is the great controversy," Nelson said, "How to find a way to make some progress, "My sense is," Nelson confirmed, "is that we're walking into anera of scientific gridlock on HIV research." That, he said, would be "disastrous,"

Nelson sharply condemned the U.S. and other developed countries that 'have not made much greater investment in scientific research on 'AIDS." . He reiterated his frustration over the fact that "in 13 years of AIDS, there are no answers. We're back in ground zero" he said.

See Your Doctor

Nelson wanted it to be "'very clear" that MAP recommends that those of its clients on drug therapy should “immediately" talk with their physicians. (basically saying if you are on AZT stop now)

From The Wisconsin Light VOLUME SIX, No. 12—June 10, 1993—June 23, 1993

http://www.mkelgbthist.org/media/print/wis-light/covers-v06-10/light-v06-12.pdf

The US major media did little to enlighten the public when it signalled the potential failure of ZDV (AZT) as therapy and the failure of CD4 as a disease marker. Instead this failure caused some fear and frustration for both patients and physicians. Burroughs Wellcome, in an effort to stem the tide of misinformation, opened the conversation about Concorde to interested media via a teleconference. While informative, it left participants with very little more than they knew before.” 1993

The Concorde Study and Its Impact on Clinical Decision-Making in HIV Care

http://online.liebertpub.com/doi/abs/10.1089/apc.1993.7.241

 

"The results of Concorde do not encourage the early use of zidovudine in symptom-free HIV-infected adults. They also call into question the uncritical use of CD4 cell counts as a surrogate endpoint for assessment of benefit from long-term antiretroviral therapy." 1994 Concorde: MRC/ANRS randomised double-blind controlled trial of immediate and deferred zidovudine in symptom-free HIV infection http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(94)90006-X/abstract

Women and children get the same dose of AZT that was used between 1987 and 1993 plus the new toxic antiretroviral Nevirapine, forward to now and the mutations are being reported

Antiretroviral Prophylaxis and the Risk of Cleft Lip and Palate: Preliminary Signal Detection in the Food and Drug Administration's Adverse Events Reporting System Database 2012

http://www.cpcjournal.org/doi/abs/10.1597/10-095

 

Helical Sun

 

 

 

 

 

 

 

 

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