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Uric acid and immune problems

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By Cal Crilly

Uric acid stimulate immune cells but uric acid crystals are really disabling immune cells because white blood cells are needed to remove it so kept busy with irritation.

Gout crystals are called tophi and the pain that create is from immune cells pouring out things to remove it.

Gout-associated uric acid crystals activate the NALP3 inflammasome

http://www.nature.com/nature/journal/v440/n7081/full/nature04516.html

So the uric acid activates immune cells but because they are busy trying to get rid of the crystals the end result is an immune system stuck in a revolving door of inflammation.

The trick is to lower uric acid so the immune cells can chase other things.

Uric acid and the immune response

http://ndt.oxfordjournals.org/content/21/11/3046.full

Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout.

http://www.ncbi.nlm.nih.gov/pubmed/19116939

The Catch 22 with people with active retroviruses on antiretrovirals is that the cure creates more uric acid.

High levels of gout may be linked to HAART

http://i-base.info/htb/11272

This can cause pre-clampsia.

“These findings demonstrate that uric acid activates the inflammasome in the trophoblast, leading to IL-1? production. This may provide a novel mechanism for the induction of inflammation at the maternal–fetal interface leading to placental dysfunction and adverse pregnancy outcome, including preeclampsia.”

Uric acid induces trophoblast IL-1? production via the inflammasome: implications for the pathogenesis of preeclampsia.

http://www.ncbi.nlm.nih.gov/pubmed/21352397

And pneumonia.

Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis.

http://www.ncbi.nlm.nih.gov/pubmed/19218193

Prognostic role of serum uric acid in acute respiratory distress syndrome patients: A preliminary study

http://www.sciencedirect.com/science/article/pii/S042276381420063X

The inflammation side effects activate immune cells which also release retroviruses.

Here they say HIV and HCV raise inflammasomes but the example of uric acid in pregnancy raising both inflammasomes and trophoblasts means uric acid is more likely to be a cause because trophoblast cells release more retroviruses than any other cells.

And trophoblast cells appear in cancer too.

HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon

http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004082

Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS

http://www.retrovirology.com/content/11/1/35

So anything that lowers inflammation is good for viral loads, the catch 22 though is that inflammation activates t-cells so in people who are too healthy the t-cells will go down if they stay on anti-inflammatory foods.

“While HAART has reduced the incidence of HIV-related morbidity and mortality, increasing evidence suggests that chronic inflammatory medical illnesses, including cardiovascular disease, diabetes mellitus, chronic kidney and liver disease, osteoporosis, and cancer occur more frequently and/or at earlier ages in HIV infected individuals. Chronic HCV is similarly associated with liver inflammation and increased risk of diabetes mellitus, kidney disease, and cancer. HIV co-infection with HCV results in enhanced progression of inflammation-linked liver and kidney pathology relative to HCV infection alone. However, the pathogenesis of HIV-1 and HCV-related chronic inflammation is complex and incompletely understood.”

Antibody-Mediated Suppression of Antiviral Inflammasome Activation

http://grantome.com/grant/NIH/R01-AI108403-02

Vegetarians for instance will have low uric acid and that means less inflammation and less t-cells.

Uric acid directly promotes human T-cell activation.

http://www.ncbi.nlm.nih.gov/pubmed/19057377

Recent developments in immune activation by uric acid crystals.

http://www.ncbi.nlm.nih.gov/pubmed/20502971

This is essentially the catch 22 of comparing the viral load test with t-cells.

Neither equates with each other, if you lower inflammation then immune cells will go down, if you raise inflammation then the viral load will go up.

For me though it gives a clear planned pathway for curing cancer.

“Recent evidence has demonstrated that elevated serum uric acid (hyperuricemia) is associated with excess cancer risk, recurrence, and mortality. Although uric acid (UA) can function as a systemic antioxidant, its pro-inflammatory properties have been postulated to play an important role in the pathogenesis of cancer. Furthermore, obesity, Type 2 Diabetes Mellitus (T2DM), and the metabolic syndrome (MetS) are also associated with excess cancer, chronic inflammation, and with hyperuricemia, suggesting that UA may represent an important link between these disorders and the development of cancer.”

Contribution of uric acid to cancer risk, recurrence, and mortality

http://www.clintransmed.com/content/1/1/16

And other inflammatory diseases where retroviruses appear such as arthritis and psoriasis and lupus.

Uric Acid May Increase Likelihood of Severe Osteoarthritis

http://corporate.dukemedicine.org/news_and_publications/news_office/news/uric-acid-may-increase-likelihood-of-severe-osteoarthritis

Heart disease and diabetes.

“Elevated serum uric acid (SUA) levels (i.e. hyperuricaemia) have been associated with metabolic syndrome (MetS) and cardiovascular disease (CVD) morbidity and mortality.”

Uric acid and diabetes: Is there a link?

http://www.ncbi.nlm.nih.gov/pubmed/23278493

And any fungal infections because fungus not only release uric acid but can use it as a food source.

Growth of Candida famata and Trichosporon cutaneum on uric acid as the sole source of carbon and energy, a hitherto unknown property of yeasts.

http://www.ncbi.nlm.nih.gov/pubmed/6651286

I just use celery as a good uric acid remover and kidney fix.

Alfalfa after meals can work and lots of vitamin C foods and reasonable water helps.

And probably movement and exercise and fresh air should be mentioned.

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